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Sandifer syndrome
Sandifer syndrome (or ''Sandifer's'' syndrome) is a 〔(【引用サイトリンク】title=Sandifer syndrome )〕 paediatric medical disorder, characterised by gastrointestinal symptoms and associated neurological features〔〔(【引用サイトリンク】title=Sandifer’s syndrome and gastro- oesophageal reflux disease )〕 There is a significant correlation between the syndrome and gastroesophageal reflux disease (GERD); however, it is estimated to occur in less than 1% of children with reflux.〔(【引用サイトリンク】title=Medscape: Medscape Access )〕
==Symptoms and signs==
Onset is usually confined to infancy and early childhood,〔 with peak prevalence at 18–36 months.〔 In rare cases, particularly where the child is severely mentally impaired, onset may extend to adolescence.〔
The classical symptoms of the syndrome are spasmodic torticollis and dystonia.〔〔〔() 〕 Nodding and rotation of the head, neck extension, gurgling, writhing movements of the limbs, and severe hypotonia have also been noted.〔
Spasms may last for 1–3 minutes and may occur up to 10 times a day. Ingestion of food is often associated with occurrence of symptoms; this may result in reluctance to feed. Associated symptoms, such as epigastric discomfort, vomiting (which may involve blood) and abnormal eye movements have been reported. Clinical signs may also include anaemia.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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